Several of the stories feature the character of Dr. Calvin, chief robopsychologist at U.S. Robots and Mechanical Men, Inc., the major manufacturer of robots. Upon their publication in this collection, Asimov wrote a framing sequence presenting the stories as Calvin's reminiscences during an interview with her about her life's work, chiefly concerned with aberrant behaviour of robots and the use of "robopsychology" to sort out what is happening in their positronic brain. The book also contains the short story in which Asimov's Three Laws of Robotics first appear, which had large influence on later science fiction and had impact on thought on ethics of artificial intelligence as well. Other characters that appear in these short stories are Powell and Donovan, a field-testing team which locates flaws in USRMM's prototype models.

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